Project B05 – Role of TET3-mediated 5mC oxidation for neuronal differentiation and plasticity
The physiological significance of TET3 proteins and their enzymatic products in the CNS has not been characterized and will be addressed with specific genetic mouse and cellular models in Aim A. TET enzymes act in concert with chromatin remodeling proteins and transcription factors. In Aim B we will assess the potential of interacting proteins to engage with TET3 and modulate its enzymatic activity. The genomic 5hmC and 5fC content in neurons varies depending on differentiation and/or activity state. In Aim C we will explore the underlying mechanism of this phenomenon.
Speaker: Prof. Dr. Thomas Carell
Ludwig-Maximilians-Universität München
Department of Chemistry Butenandtstr. 5 - 13
81377 Munich Germany
Phone: +49 (0)89 2180-77750
Fax: +49 (0)89 2180-77756
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Managing Director: Dr. Oliver Baron
Institute for Chemical Epigenetics Munich (ICEM)
Ludwig-Maximilians-Universität München
Butenandtstr. 5 - 13
81377 Munich Germany
Phone: +49 (0)89 2180-77661
Fax: +49 (0)89 2180-77651
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Secretary: Birgit Carell
Butenandtstr. 5 - 13 - Haus F 5.010
81377 Munich Germany
Phone: +49 (0)89 2180-77751
Fax: +49 (0)89 2180-77881
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Prof. Dr. Hendrik Zipse (Spokesman)
LMU Munich
Department of Chemistry
Butenandtstr. 5 - 13
House F, Room 3.084
81377 Munich, Germany
Phone: +49 89 2180 77737
Fax: +49 89 2180-77738
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Dr. Stefanie Kellner (Deputy Spokeswoman)
LMU Munich
Department of Chemistry
Butenandtstr. 5 - 13
House F, Room 1.054 und House B, Room 2.073
81377 Munich Germany
Phone: +49 89 2180 77737
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Dr. Martin Sumser (Coordinator)
LMU Munich
Department of Chemistry
Butenandtstr. 5 - 13
House F, Room 4.086
81377 Munich Germany
Phone: +49 89 2180 77765
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