Project A04 – Molecular mechanism of active demethylation
Since 2009 three new DNA bases (5-hydroxymethyl-, 5-formyl-, and 5-carboxy-cytidine, hmdC, fdC and cadC) were discovered that are present in the DNA isolated from stem cells and neurons. We believe that fdC and cadC undergo deformylation and decarboxylation reactions to establish a new, long search for, pathway to active demethylation. In this project, we plan to gain direct in vivo evidence for the existence of the putative decarboxylation reaction and we plan to make the first steps towards identifying the decarboxylating entity in stem cells. In the second part of the project, we plan to develop new, robust sequencing methods that will allow us to determine the positions of hmdC and fdC in the genome..
Speaker: Prof. Dr. Thomas Carell
Ludwig-Maximilians-Universität München
Department of Chemistry Butenandtstr. 5 - 13
81377 Munich Germany
Phone: +49 (0)89 2180-77750
Fax: +49 (0)89 2180-77756
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Managing Director: Dr. Oliver Baron
Institute for Chemical Epigenetics Munich (ICEM)
Ludwig-Maximilians-Universität München
Butenandtstr. 5 - 13
81377 Munich Germany
Phone: +49 (0)89 2180-77661
Fax: +49 (0)89 2180-77651
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Secretary: Birgit Carell
Butenandtstr. 5 - 13 - Haus F 5.010
81377 Munich Germany
Phone: +49 (0)89 2180-77751
Fax: +49 (0)89 2180-77881
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Prof. Dr. Hendrik Zipse (Spokesman)
LMU Munich
Department of Chemistry
Butenandtstr. 5 - 13
House F, Room 3.084
81377 Munich, Germany
Phone: +49 89 2180 77737
Fax: +49 89 2180-77738
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Dr. Stefanie Kellner (Deputy Spokeswoman)
LMU Munich
Department of Chemistry
Butenandtstr. 5 - 13
House F, Room 1.054 und House B, Room 2.073
81377 Munich Germany
Phone: +49 89 2180 77737
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Dr. Martin Sumser (Coordinator)
LMU Munich
Department of Chemistry
Butenandtstr. 5 - 13
House F, Room 4.086
81377 Munich Germany
Phone: +49 89 2180 77765
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