SFB 1309
Bromodomain AAA+ ATPases get into shape
2020-03-19
Magdalena Murawska and Andreas G. Ladurner
Nucleus, 2020, 11:1, 32–34
Bromodomain AAA+ ATPases (ATPases associated with diverse cellular activities) are emerging as oncogenic proteins and compelling targets for anticancer therapies. However, structural and biochemical insight into these machines is missing. A recent study by Cho et al. reports the first cryo-EM structure of a bromodomain AAA+ ATPase and provides first insights into the functions of this putative histone chaperone.
