Wie das Histon-Chaperon FACT aktives und stilles Chromatin bewahrt

2021-03-01

MAGDALENA MURAWSKA, ANDREAS G. LADURNER

BIOspektrum, 2021, 03.21

https://www.biospektrum.de/magazinartikel/wie-das-histon-chaperon-fact-aktives-und-stilles-chromatin-bewahrt?dl=1

Histone chaperones play a fundamental role in the regulation of genome dynamics and stability. They are a versatile group of proteins that interact with histone proteins and govern their assembly or disassembly into nucleosomes. How the activity of histone chaperones is regulated is not well understood. Here, we discuss our new data on how histone post-transcriptional modifications cooperate with the essential histone chaperone complex FACT in active and silent regions of the genome.